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KMID : 0359319850250010033
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Korean Journal of Veterinary Research
1985 Volume.25 No. 1 p.33 ~ p.40
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Inhibitory Action of Oxymetazoline on Movements of The Isolated Strips of Rabbit Small Intestine ; A Comparison of Recordings Through Isotonic Transducer and Through Isometric Transducer
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Abstract
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The inhibitory action of oxymetazoline on the spontaneous movements of isolated intestinal strips of the rabbit and the effects of antagonists upon the oxymetazoline actions were assessed with recordings through both isometric and isotonic transducers, and comparisons were made between both methods of recording.
There were significant differences between the slopes of regression equations calculated from log dose response curves of oxymetazoline obtained from jejunum and those from ileum. But no difference was noted between both recordings either through isotonic transducer or through isometric transducer. The ID_(50) of oxymetazoline obtained from the recording through isotonic transducer was 6.31×10＾(-7)M in jejunum and 3.16×10＾(-8)M in ileum. The recording through isometric transducer gave the values of 5.01×10＾(-7)M in jejunum and 1.07×10＾-8M in ileum. The pA₂-values of prazosin to oxymetazoline calculated from the recording through isotonic transducer were 8.13 in jejunum and 8.31 in ileum and the recording through isometric transducer gave the values of 7.29 and 8.26 in jejunum and ileum, respectively. The pA₂-values of phentolamine to oxymetazoline obtained from the recording through isotonic transducer were 8.18 in Jejunum and 9.31 in ileum and those from the recording through isometric transducer were 7.75 and8.13 in jejunum and ileum, respectively.
These results indicate that there are no significant differences between recordings either through isotonic transducer or through isometric transducer in assessing inhibitory responses of intestinal movement to certain drugs.
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